New Study Shows No Remdesivir Benefit for COVID Patients

[DrSchadenfreude]

New study on Gilead’s remdesivir show no benefit for coronavirus patients.

www.statnews.com/2020/04/23/data-on-gileads-remdesivir-released-by-accident-show-no-benefit-for-coronavirus-patients/

April 23, 2020

The antiviral medicine remdesivir from Gilead Sciences failed to speed the improvement of patients with Covid-19 or prevent them from dying, according to results from a long-awaited clinical trial conducted in China. Gilead, however, said the data suggest a “potential benefit.”

A summary of the study results was inadvertently posted to the website of the World Health Organization and seen by STAT on Thursday, but then removed.

“A draft document was provided by the authors to WHO and inadvertently posted on the website and taken down as soon as the mistake was noticed. The manuscript is undergoing peer review and we are waiting for a final version before WHO comments,” said WHO spokesperson Tarik Jasarevic.

Gilead spokesperson Amy Flood said the company believes “the post included inappropriate characterization of the study.” Because the study was stopped early because it had too few patients, she said, it cannot “enable statistically meaningful conclusions.” However, she said, “trends in the data suggest a potential benefit for remdesivir, particularly among patients treated early in disease.”

The data (for details, see screenshot below) will be closely scrutinized but are also likely imperfect. The study was terminated prematurely, which could have affected the results. The context that would be provided by a full manuscript is missing, and the data have not been reviewed as normally occurs before publication.


Many studies are being run to test remdesivir, and this one will not be the final word. Results are expected soon from a Gilead-run study in severe Covid-19 patients, although that study may be difficult to interpret because the drug is not compared to patients receiving only standard treatment. Encouraging data from patients in that study at the University of Chicago were described by researchers at a virtual town hall and obtained by STAT last week. However, unlike those data, these new results are from a randomized controlled trial, the medical gold standard.

Gilead is also running a study with a control group in more moderate Covid-19 patients, and the National Institute of Allergy and Infectious Diseases is running a study that compares remdesivir to placebo. There are even more studies of the drug ongoing.

According to the summary of the China study, remdesivir was “not associated with a difference in time to clinical improvement” compared to a standard of care control. After one month, it appeared 13.9% of the remdesivir patients had died compared to 12.8% of patients in the control arm. The difference was not statistically significant.

“In this study of hospitalized adult patients with severe COVID-19 that was terminated prematurely, remdesivir was not associated with clinical or virological benefits,” the summary states. The study was terminated prematurely because it was difficult to enroll patients in China, where the number of Covid-19 cases was decreasing.

An outside researcher said that the results mean that any benefit from remdesivir is likely to be small.

“If there is no benefit to remdesivir in a study this size, this suggests that the overall benefit of remdesivir in this population with advanced infection is likely to be small in the larger Gilead trial,” said Andrew Hill, senior visiting research fellow at Liverpool University.

He added that the results of the study should be pooled with larger studies being conducted by Gilead using a technique called meta-analysis to allow for “a balanced view of the efficacy of remdesivir from all randomized trials.”
Newsletters

[AlaCowboy]

One would think that someone claiming to be a medical doctor and Harvard Medical School graduate would be able to understand science and medical studies. The China study was limited to seriously and critically ill patients, and was terminated early. Other studies and experimental treatments show that when Remdesivir is administered early in the Covid-19 treatment improvement is shown in a majority of patients treated. I recently posted the comments of a doctor in Birmingham, Alabama, who was treated with Remdesivir early in his illness and he recovered.
Walter should review comments from a lying hack like The Fake Doctor From Denver and move them to The Sandbox where they belong.

[DrSchadenfreude]

Apr 23, 2020 17:53:31 GMT -5 AlaCowboy said:

One would think that someone claiming to be a medical doctor and Harvard Medical School graduate would be able to understand science and medical studies. The China study was limited to seriously and critically ill patients, and was terminated early. Other studies and experimental treatments show that when Remdesivir is administered early in the Covid-19 treatment improvement is shown in a majority of patients treated. I recently posted the comments of a doctor in Birmingham, Alabama, who was treated with Remdesivir early in his illness and he recovered.
Walter should review comments from a lying hack like The Fake Doctor From Denver and move them to The Sandbox where they belong.

Dung-head,

     FYI.  You still owe me $1,000 for your 4/27/15 bet that I am not a graduate of Harvard Medical School's class of '83.  You're coming up on your 5th anniversary as a welcher here.

     Remember when I posted a notarized copy of my HMS diploma, after you refused to accept a fax or an Email?

    As for the Gilead drug, we'll see.  I posted this latest preliminary study as an FYI.

[AlaCowboy]

Apr 23, 2020 18:18:41 GMT -5 DrSchadenfreude said:

Apr 23, 2020 17:53:31 GMT -5 AlaCowboy said:

One would think that someone claiming to be a medical doctor and Harvard Medical School graduate would be able to understand science and medical studies. The China study was limited to seriously and critically ill patients, and was terminated early. Other studies and experimental treatments show that when Remdesivir is administered early in the Covid-19 treatment improvement is shown in a majority of patients treated. I recently posted the comments of a doctor in Birmingham, Alabama, who was treated with Remdesivir early in his illness and he recovered.
Walter should review comments from a lying hack like The Fake Doctor From Denver and move them to The Sandbox where they belong.

Dung-head,

     FYI.  You still owe me $1,000 for your 4/27/15 bet that I am not a graduate of Harvard Medical School's class of '83.  You're coming up on your 5th anniversary as a welcher here.

     Remember when I posted a notarized copy of my HMS diploma, after you refused to accept a fax or an Email?

    As for the Gilead drug, we'll see.  I posted this latest preliminary study as an FYI.

You posted a phony degree you bought off the internet. I have a Harvard Medical School degree on my wall just like yours. There is no way to prove that YOU are who you claim to be.

[DrSchadenfreude]

Apr 23, 2020 21:43:15 GMT -5 AlaCowboy said:

Apr 23, 2020 18:18:41 GMT -5 DrSchadenfreude said:

Dung-head,

     FYI.  You still owe me $1,000 for your 4/27/15 bet that I am not a graduate of Harvard Medical School's class of '83.  You're coming up on your 5th anniversary as a welcher here.

     Remember when I posted a notarized copy of my HMS diploma, after you refused to accept a fax or an Email?

    As for the Gilead drug, we'll see.  I posted this latest preliminary study as an FYI.

You posted a phony degree you bought off the internet. I have a Harvard Medical School degree on my wall just like yours. There is no way to prove that YOU are who you claim to be.

Says the lying screwball who refused to accept a confirmatory fax, Email, phone call, or even a private message (PM) on this sports forum-- while continuing to post scurrilous nonsense for the past five years!

You're pathetic.

[daleko]

Apr 23, 2020 22:15:39 GMT -5 DrSchadenfreude said:

Apr 23, 2020 21:43:15 GMT -5 AlaCowboy said:

You posted a phony degree you bought off the internet. I have a Harvard Medical School degree on my wall just like yours. There is no way to prove that YOU are who you claim to be.

Says the lying screwball who refused to accept a confirmatory fax, Email, phone call, or even a private message (PM) on this sports forum-- while continuing to post scurrilous nonsense for the past five years!

You're pathetic.

Stop Willie. I’ve already told you the biggest issue. The degree is real as is the Dr but there is no way to prove who posted the info. Who typed the info. Can’t. Any number of reasons why you may have gotten a certified copy, if you weren’t Ambrose. The simplest being he gave it to you after you spun a story or not. 

[Deleted]

Apr 23, 2020 23:56:29 GMT -5 daleko said:

Apr 23, 2020 22:15:39 GMT -5 DrSchadenfreude said:

Says the lying screwball who refused to accept a confirmatory fax, Email, phone call, or even a private message (PM) on this sports forum-- while continuing to post scurrilous nonsense for the past five years!

You're pathetic.

Stop Willie. I’ve already told you the biggest issue. The degree is real as is the Dr but there is no way to prove who posted the info. Who typed the info. Can’t. Any number of reasons why you may have gotten a certified copy, if you weren’t Ambrose. The simplest being he gave it to you after you spun a story or not. 

Traitor Willie thinks that people are capable of creating holographic airliners to fly into the world trade center and destroy it.   He also thinks they can create an imaginary cruise missile that flies into the Pentagon and explodes, leaving AIRPLANE parts behind.

Yet he seems not to understand that ANYONE can forge official looking documents from universities, law schools, state bar rolls, and anything else.

IOW, "documents" with his name on them are proof of NOTHING.

Williegirl is a known and proven liar, and is most likely in real life a convicted sex offender who has been in and out of mental institutions, as an INMATE.

[DrSchadenfreude]

Not sure who is more pathetic-- the habitually lying Cowboy from Huntsville, or his cadre of dishonest enablers on this forum.

Whatever.   As far as I'm concerned, it's between you fellas and the Lord at this point.

I'm not your judge.

We all make mistakes, and we all need to repent.

[daleko]

Apr 24, 2020 7:37:51 GMT -5 @muttthemaster said:

Apr 23, 2020 23:56:29 GMT -5 daleko said:

Stop Willie. I’ve already told you the biggest issue. The degree is real as is the Dr but there is no way to prove who posted the info. Who typed the info. Can’t. Any number of reasons why you may have gotten a certified copy, if you weren’t Ambrose. The simplest being he gave it to you after you spun a story or not. 

Traitor Willie thinks that people are capable of creating holographic airliners to fly into the world trade center and destroy it.   He also thinks they can create an imaginary cruise missile that flies into the Pentagon and explodes, leaving AIRPLANE parts behind.

Yet he seems not to understand that ANYONE can forge official looking documents from universities, law schools, state bar rolls, and anything else.

IOW, "documents" with his name on them are proof of NOTHING.

Williegirl is a known and proven liar, and is most likely in real life a convicted sex offender who has been in and out of mental institutions, as an INMATE.

Doesn't have to be phony. The Doctor's name is real. He had an office at XXX street in Denver. His practice was real. He did a lot of good in the community. More than some here. He lived in a real house at XXX street. Drove a real SUV w license plate # XXX. His daughter drove a real car that was white. Has a real wife who was a noted psychologist. A wonderful daughter. Nice house on a nice street. The photocopy of the degree is probably real. The certification by a Notary is probably real.

What he can't prove is who is typing the posts. IF it's not the MD, that's IF, any number of reasons how he arrived at securing it.The simplist being it was given to him. And for that reason the bet is null and void. End of conversation. The rest of it is all BS. IP adress is meaningless, as it only shows a general neighborhood and the posts had several IPs, in any case. If he isn't who he said he is, why? Any number of reasons.

But the topic is the bet. He can't prove that he, if he is the MD, is the one doing the typing, creating the posts. Could be the patient, a different well educated, smart guy or a person w  little formal edu but access to the www and the info it has on just about anything.

It was a dumb bet by Willie, nee Ambrose, nee X, because he couln't definitvely prove who is creating the posts. Case closed.

[DrSchadenfreude]

Apr 24, 2020 12:30:16 GMT -5 daleko said:

Apr 24, 2020 7:37:51 GMT -5 @muttthemaster said:

Traitor Willie thinks that people are capable of creating holographic airliners to fly into the world trade center and destroy it.   He also thinks they can create an imaginary cruise missile that flies into the Pentagon and explodes, leaving AIRPLANE parts behind.

Yet he seems not to understand that ANYONE can forge official looking documents from universities, law schools, state bar rolls, and anything else.

IOW, "documents" with his name on them are proof of NOTHING.

Williegirl is a known and proven liar, and is most likely in real life a convicted sex offender who has been in and out of mental institutions, as an INMATE.

Doesn't have to be phony. The Doctor's name is real. He had an office at XXX street in Denver. His practice was real. He did a lot of good in the community. More than some here. He lived in a real house at XXX street. Drove a real SUV w license plate # XXX. His daughter drove a real car that was white. Has a real wife who was a noted psychologist. A wonderful daughter. Nice house on a nice street. The photocopy of the degree is probably real. The certification by a Notary is probably real.

What he can't prove is who is typing the posts. IF it's not the MD, that's IF, any number of reasons how he arrived at securing it.The simplist being it was given to him. And for that reason the bet is null and void. End of conversation. The rest of it is all BS. IP adress is meaningless, as it only shows a general neighborhood and the posts had several IPs, in any case. If he isn't who he said he is, why? Any number of reasons.

But the topic is the bet. He can't prove that he, if he is the MD, is the one doing the typing, creating the posts. Could be the patient, a different well educated, smart guy or a person w  little formal edu but access to the www and the info it has on just about anything.

It was a dumb bet by Willie, nee Ambrose, nee X, because he couln't definitvely prove who is creating the posts. Case closed.

You left out the parts about; 

1) Cowboy offering the (derogatory) bet in the first place.

2)  Cowboy demanding to see (within 24 hours) a notarized copy of my medical diploma, along with the name and phone number of the notary public-- both of which I obtained during my lunch break the following day (from the law firm next to my office--it took about five minutes.)

3)  Cowboy then refusing to receive a copy by fax, Email, or PM-- at which point I posted the notarized copy for him on the "Wager" board.

4)  Lee F-- confirming for Cowboy that he had, in fact, received a baptismal gift/package from me with my return address on it.

[AlaCowboy]

Apr 24, 2020 13:51:32 GMT -5 DrSchadenfreude said:

Apr 24, 2020 12:30:16 GMT -5 daleko said:

Doesn't have to be phony. The Doctor's name is real. He had an office at XXX street in Denver. His practice was real. He did a lot of good in the community. More than some here. He lived in a real house at XXX street. Drove a real SUV w license plate # XXX. His daughter drove a real car that was white. Has a real wife who was a noted psychologist. A wonderful daughter. Nice house on a nice street. The photocopy of the degree is probably real. The certification by a Notary is probably real.

What he can't prove is who is typing the posts. IF it's not the MD, that's IF, any number of reasons how he arrived at securing it.The simplist being it was given to him. And for that reason the bet is null and void. End of conversation. The rest of it is all BS. IP adress is meaningless, as it only shows a general neighborhood and the posts had several IPs, in any case. If he isn't who he said he is, why? Any number of reasons.

But the topic is the bet. He can't prove that he, if he is the MD, is the one doing the typing, creating the posts. Could be the patient, a different well educated, smart guy or a person w  little formal edu but access to the www and the info it has on just about anything.

It was a dumb bet by Willie, nee Ambrose, nee X, because he couln't definitvely prove who is creating the posts. Case closed.

You left out the parts about; 

1) Cowboy offering the (derogatory) bet in the first place.

2)  Cowboy demanding to see (within 24 hours) a notarized copy of my medical diploma, along with the name and phone number of the notary public-- both of which I obtained during my lunch break the following day (from the law firm next to my office--it took about five minutes.)

3)  Cowboy then refusing to receive a copy by fax, Email, or PM-- at which point I posted the notarized copy for him on the "Wager" board.

4)  Lee F-- confirming for Cowboy that he had, in fact, received a baptismal gift/package from me with my return address on it.

So if I send to your home (I assume you don't have an office anymore) a letter with the return address of 3764 Elvis Presley Boulevard, Memphis, Tn., 38116, will you tell all your friends you got a letter from Elvis? Who cares what return address some idiot put on an envelope or package he may have mailed from Paducah, Ky.?

[daleko]

Apr 24, 2020 13:51:32 GMT -5 DrSchadenfreude said:

Apr 24, 2020 12:30:16 GMT -5 daleko said:

You left out the parts about; 

1) Cowboy offering the (derogatory) bet in the first place. You are & were still the dumbass.

2)  Cowboy demanding to see (within 24 hours) a notarized copy of my medical diploma, along with the name and phone number of the notary public-- both of which I obtained during my lunch break the following day (from the law firm next to my office--it took about five minutes.) Or someone else had it done. Maybe you and the MD were/are banging the same NR admin.
3)  Cowboy then refusing to receive a copy by fax, Email, or PM-- at which point I posted the notarized copy for him on the "Wager" board. He's a smart guy and, at that time, strange letters w white powder were suspect, assuming you have his address, which, I believe you don't.

4)  Lee F-- confirming for Cowboy that he had, in fact, received a baptismal gift/package from me with my return address on it. I had several letters from the White House w various POTUSs on it, which were bogus. BFD.

[DrSchadenfreude]

Apr 24, 2020 19:04:59 GMT -5 daleko said:

Apr 24, 2020 13:51:32 GMT -5 DrSchadenfreude said:

You left out the parts about; 

1) Cowboy offering the (derogatory) bet in the first place. You are & were still the dumbass.

2)  Cowboy demanding to see (within 24 hours) a notarized copy of my medical diploma, along with the name and phone number of the notary public-- both of which I obtained during my lunch break the following day (from the law firm next to my office--it took about five minutes.) Or someone else had it done. Maybe you and the MD were/are banging the same NR admin.
3)  Cowboy then refusing to receive a copy by fax, Email, or PM-- at which point I posted the notarized copy for him on the "Wager" board. He's a smart guy and, at that time, strange letters w white powder were suspect, assuming you have his address, which, I believe you don't.

4)  Lee F-- confirming for Cowboy that he had, in fact, received a baptismal gift/package from me with my return address on it. I had several letters from the White House w various POTUSs on it, which were bogus. BFD.

Daleko,

      How do you explain Cowboy's refusal to accept a faxed copy, Email, or even a Pro Boards PM of my notarized diploma-- within 24 hours of his bet-- after he demanded proof in the form of a notarized copy, with the contact info for the notary?  (Which I posted here.)

     Explain.  I'll wait.

[Deleted]

Apr 24, 2020 12:30:16 GMT -5 daleko said:

Apr 24, 2020 7:37:51 GMT -5 @muttthemaster said:

Traitor Willie thinks that people are capable of creating holographic airliners to fly into the world trade center and destroy it.   He also thinks they can create an imaginary cruise missile that flies into the Pentagon and explodes, leaving AIRPLANE parts behind.

Yet he seems not to understand that ANYONE can forge official looking documents from universities, law schools, state bar rolls, and anything else.

IOW, "documents" with his name on them are proof of NOTHING.

Williegirl is a known and proven liar, and is most likely in real life a convicted sex offender who has been in and out of mental institutions, as an INMATE.

Doesn't have to be phony. The Doctor's name is real. He had an office at XXX street in Denver. His practice was real. He did a lot of good in the community. More than some here. He lived in a real house at XXX street. Drove a real SUV w license plate # XXX. His daughter drove a real car that was white. Has a real wife who was a noted psychologist. A wonderful daughter. Nice house on a nice street. The photocopy of the degree is probably real. The certification by a Notary is probably real.

What he can't prove is who is typing the posts. IF it's not the MD, that's IF, any number of reasons how he arrived at securing it.The simplist being it was given to him. And for that reason the bet is null and void. End of conversation. The rest of it is all BS. IP adress is meaningless, as it only shows a general neighborhood and the posts had several IPs, in any case. If he isn't who he said he is, why? Any number of reasons.

But the topic is the bet. He can't prove that he, if he is the MD, is the one doing the typing, creating the posts. Could be the patient, a different well educated, smart guy or a person w  little formal edu but access to the www and the info it has on just about anything.

It was a dumb bet by Willie, nee Ambrose, nee X, because he couln't definitvely prove who is creating the posts. Case closed.

That would be identity theft, which isn't much different than using phony documents.   Either way, the criminal is pretending to be someone he is not.

The person posting here, using that name, is simply an attention whore who has never accomplished anything worthwhile in his LIFE. 

Most likely a mental patient.

[daleko]

Apr 24, 2020 19:14:04 GMT -5 DrSchadenfreude said:

Apr 24, 2020 19:04:59 GMT -5 daleko said:

Daleko,

      How do you explain Cowboy's refusal to accept a faxed copy, Email, or even a Pro Boards PM of my notarized diploma-- within 24 hours of his bet-- after he demanded proof in the form of a notarized copy, with the contact info for the notary?  (Which I posted here.)

     Explain.  I'll wait.

All not P2P. Easily fabricated. Not that was necessarily the case, as it involved you.