Post by Panama pfRedd on Sept 25, 2021 12:34:16 GMT -5
A study from Saudi Arabia on vitamin D3 supplementation to assist with covid recovery. I've been taking D3 for years but upped it to 5000 IU at the start of the covid era.
Excerpt:
Preliminary trials on the use of vitamin D supplementation against COVID-19 are limited but accumulating. In a pilot study done in Spain, early high dose vitamin D3 prevented ICU admission among COVID-19 patients in combination with the best available standard care for severe cases [31]. In a case-series of COVID-19 patients who received 50,000 IU daily for 5 days, a marked reduction in recovery time and inflammatory markers were observed compared to those who received 1000 IU [32]. A recent quasi-experimental study also showed that among the frail elderly with COVID-19, those who received boluses of 50,000 IU per month or 80,000–100,000 IU per 2–3 months were associated with less severe and improved survival (OR = 0.08 (0.01: 0.81), p = 0.03) [33]. Among the negative trials, a single high dose vitamin D (200,000 IU) given to severe COVID-19 patients (n = 114) did not reduce the hospital stay and severity of outcome compared to the placebo group (n = 118) (Hazard Ratio 1.12) [34]. The trials mentioned have mostly focused on severe cases and mega-doses of vitamin D compared to the present study, which focused on mild cases and lower daily vitamin D doses. In a large-scale meta-analysis conducted involving almost 11,000 participants in 25 clinical trials on the prevention of acute respiratory infections, the protective effects were the greatest among those vitamin D deficient individuals who received daily or weekly doses as opposed to boluses [9]. The dose used in the present study is somewhat similar to a previous RCT, which demonstrated, albeit during a longer term (12 months), that the supplementation of 4000 IU Vitamin D3 prevented acute respiratory infections by as much as 36% (Relative Risk 0.64, 95 % CI 0.43–0.94) based on a cohort of 140 adults with increased risk of acute respiratory infections (>4 infections/year) [35].
Conclusions
In summary, a 2-week oral supplementation of 5000 IU vitamin D3 was superior to 1000 IU in resolving cough and gustatory sensory loss among COVID-19 patients with sub-optimal vitamin D presenting with mild to moderate symptoms. The present findings add to the growing body of evidence on the beneficial effects of vitamin D supplementation against COVID-19, particularly among those with suboptimal levels.
www.ncbi.nlm.nih.gov/pmc/articles/PMC8308273/
Excerpt:
Preliminary trials on the use of vitamin D supplementation against COVID-19 are limited but accumulating. In a pilot study done in Spain, early high dose vitamin D3 prevented ICU admission among COVID-19 patients in combination with the best available standard care for severe cases [31]. In a case-series of COVID-19 patients who received 50,000 IU daily for 5 days, a marked reduction in recovery time and inflammatory markers were observed compared to those who received 1000 IU [32]. A recent quasi-experimental study also showed that among the frail elderly with COVID-19, those who received boluses of 50,000 IU per month or 80,000–100,000 IU per 2–3 months were associated with less severe and improved survival (OR = 0.08 (0.01: 0.81), p = 0.03) [33]. Among the negative trials, a single high dose vitamin D (200,000 IU) given to severe COVID-19 patients (n = 114) did not reduce the hospital stay and severity of outcome compared to the placebo group (n = 118) (Hazard Ratio 1.12) [34]. The trials mentioned have mostly focused on severe cases and mega-doses of vitamin D compared to the present study, which focused on mild cases and lower daily vitamin D doses. In a large-scale meta-analysis conducted involving almost 11,000 participants in 25 clinical trials on the prevention of acute respiratory infections, the protective effects were the greatest among those vitamin D deficient individuals who received daily or weekly doses as opposed to boluses [9]. The dose used in the present study is somewhat similar to a previous RCT, which demonstrated, albeit during a longer term (12 months), that the supplementation of 4000 IU Vitamin D3 prevented acute respiratory infections by as much as 36% (Relative Risk 0.64, 95 % CI 0.43–0.94) based on a cohort of 140 adults with increased risk of acute respiratory infections (>4 infections/year) [35].
Conclusions
In summary, a 2-week oral supplementation of 5000 IU vitamin D3 was superior to 1000 IU in resolving cough and gustatory sensory loss among COVID-19 patients with sub-optimal vitamin D presenting with mild to moderate symptoms. The present findings add to the growing body of evidence on the beneficial effects of vitamin D supplementation against COVID-19, particularly among those with suboptimal levels.
www.ncbi.nlm.nih.gov/pmc/articles/PMC8308273/
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