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Post by dilligaf on Feb 23, 2022 12:10:39 GMT -5
Since their official stance is anti-gun, AMA and their official comic book can all go take a flying leap. Noting that guns are involved in a large number of deaths in America is just a plain fact. Killing the messenger won't change that. Murders are not public health issues. They are POLICE issues. Attacking a particular inanimate TOOL is not a doctor's job, either. If my doctor tells me he thinks any of my guns are going to walk out the door and kill people, I will change doctors IMMEDIATELY.
Let me straighten you out ...........
Guns are involved in many murders, but MURDERERS are involved in ALL of them. Did that help you connect the dots of reality and true FACT?
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Post by Walter on Feb 23, 2022 16:45:20 GMT -5
Noting that guns are involved in a large number of deaths in America is just a plain fact. Killing the messenger won't change that. Murders are not public health issues. They are POLICE issues. Attacking a particular inanimate TOOL is not a doctor's job, either. If my doctor tells me he thinks any of my guns are going to walk out the door and kill people, I will change doctors IMMEDIATELY.
Let me straighten you out ...........
Guns are involved in many murders, but MURDERERS are involved in ALL of them. Did that help you connect the dots of reality and true FACT?
Suicide is a psych issue, e.g. MEDICAL. Approx. half of gun deaths are suicides. Hence, guns are a public health issue. Deal with it. |
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Post by cbisbig on Feb 23, 2022 19:56:37 GMT -5
Murders are not public health issues. They are POLICE issues. Attacking a particular inanimate TOOL is not a doctor's job, either. If my doctor tells me he thinks any of my guns are going to walk out the door and kill people, I will change doctors IMMEDIATELY.
Let me straighten you out ...........
Guns are involved in many murders, but MURDERERS are involved in ALL of them. Did that help you connect the dots of reality and true FACT?
Suicide is a psych issue, e.g. MEDICAL. Approx. half of gun deaths are suicides. Hence, guns are a public health issue. Deal with it. You dont think someone wanting to kill themselves wouldn't find something besides a gun. Guns are just a faster way to do the deed. Plenty of other ways to get it done |
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Post by dilligaf on Feb 23, 2022 22:42:28 GMT -5
Murders are not public health issues. They are POLICE issues. Attacking a particular inanimate TOOL is not a doctor's job, either. If my doctor tells me he thinks any of my guns are going to walk out the door and kill people, I will change doctors IMMEDIATELY.
Let me straighten you out ...........
Guns are involved in many murders, but MURDERERS are involved in ALL of them. Did that help you connect the dots of reality and true FACT?
Suicide is a psych issue, e.g. MEDICAL. Approx. half of gun deaths are suicides. Hence, guns are a public health issue. Deal with it. Wrong. Suicide is a mental health issue and has nothing to do with the instrument used to carry it out. FTR, since you are ignorant of it, most women do NOT shoot themselves. They OD on pills or slit their wrists. You shouldn't discuss things you don't know anything about.
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Post by dilligaf on Feb 23, 2022 22:43:55 GMT -5
Suicide is a psych issue, e.g. MEDICAL. Approx. half of gun deaths are suicides. Hence, guns are a public health issue. Deal with it. You dont think someone wanting to kill themselves wouldn't find something besides a gun. Guns are just a faster way to do the deed. Plenty of other ways to get it done |
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Post by Walter on Feb 23, 2022 23:49:25 GMT -5
Suicide is a psych issue, e.g. MEDICAL. Approx. half of gun deaths are suicides. Hence, guns are a public health issue. Deal with it. You dont think someone wanting to kill themselves wouldn't find something besides a gun. Guns are just a faster way to do the deed. Plenty of other ways to get it done Way more male suicides are successful than female attempts because fewer women use guns. Those women who fail, and/or have second thoughts and call for help represent a significant difference in outcome. And not everyone who attempts and fails tries again. That is a public health issue worthy of study, no? |
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Post by cbisbig on Feb 24, 2022 6:37:44 GMT -5
You dont think someone wanting to kill themselves wouldn't find something besides a gun. Guns are just a faster way to do the deed. Plenty of other ways to get it done Way more male suicides are successful than female attempts because fewer women use guns. Those women who fail, and/or have second thoughts and call for help represent a significant difference in outcome. And not everyone who attempts and fails tries again. That is a public health issue worthy of study, no? Where does your stats and info come from? |
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Post by Walter on Feb 24, 2022 8:45:48 GMT -5
Way more male suicides are successful than female attempts because fewer women use guns. Those women who fail, and/or have second thoughts and call for help represent a significant difference in outcome. And not everyone who attempts and fails tries again. That is a public health issue worthy of study, no? Where does your stats and info come from? LOL...It might have come from a study, but conservative gun nuts banned such things. Nevertheless, it is fairly common knowledge. There are a lot of factors, and method of attempt is but one. It is a complicated issue and deservres further study, but nooooo...not if gun nuts have anything to say about it. www.verywellmind.com/gender-differences-in-suicide-methods-1067508 |
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Post by DrSchadenfreude on Mar 18, 2022 10:34:26 GMT -5
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Post by cbisbig on Mar 18, 2022 14:11:47 GMT -5
truthnewsnet.org/new-study-confirms-ivermectin-outperforms-other-options/An analysis of all 10 drugs found that ivermectin was the most effective drug candidate against the Omicron variant. The testing included Nirmatrelvir (Paxlovid), which is the new protease inhibitor for which the FDA provided an emergency use authorization against COVID in December 2021. In other words, Pfizer released a new drug which cost the U.S. taxpayers $5.29 billion or $529 per course of treatment and which received a EUA despite the availability of a similar drug that has proven to be more effective and is cheaper, priced between $48 and $95 for 20 pills depending on your location.
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Post by Walter on Mar 18, 2022 14:27:01 GMT -5
truthnewsnet.org/new-study-confirms-ivermectin-outperforms-other-options/An analysis of all 10 drugs found that ivermectin was the most effective drug candidate against the Omicron variant. The testing included Nirmatrelvir (Paxlovid), which is the new protease inhibitor for which the FDA provided an emergency use authorization against COVID in December 2021. In other words, Pfizer released a new drug which cost the U.S. taxpayers $5.29 billion or $529 per course of treatment and which received a EUA despite the availability of a similar drug that has proven to be more effective and is cheaper, priced between $48 and $95 for 20 pills depending on your location. Unfortunately, there is no link to the study. Post a link to the actual study. |
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Post by cbisbig on Mar 18, 2022 15:17:48 GMT -5
truthnewsnet.org/new-study-confirms-ivermectin-outperforms-other-options/An analysis of all 10 drugs found that ivermectin was the most effective drug candidate against the Omicron variant. The testing included Nirmatrelvir (Paxlovid), which is the new protease inhibitor for which the FDA provided an emergency use authorization against COVID in December 2021. In other words, Pfizer released a new drug which cost the U.S. taxpayers $5.29 billion or $529 per course of treatment and which received a EUA despite the availability of a similar drug that has proven to be more effective and is cheaper, priced between $48 and $95 for 20 pills depending on your location. Unfortunately, there is no link to the study. Post a link to the actual study. The link was at the bottom of the page all of the resource links from the article are at the bottom of the page arxiv.org/abs/2201.08176v1Submitted on 20 Jan 2022] Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity and possible therapeutics Md Sorwer Alam Parvez, Manash Kumar Saha, Md. Ibrahim, Yusha Araf, Md. Taufiqul Islam, Gen Ohtsuki, Mohammad Jakir Hosen Prominently accountable for the upsurge of COVID-19 cases as the world attempts to recover from the previous two waves, Omicron has further threatened the conventional therapeutic approaches. Omicron is the fifth variant of concern (VOC), which comprises more than 10 mutations in the receptor-binding domain (RBD) of the spike protein. However, the lack of extensive research regarding Omicron has raised the need to establish correlations to understand this variant by structural comparisons. Here, we evaluate, correlate, and compare its genomic sequences through an immunoinformatic approach with wild and mutant RBD forms of the spike protein to understand its epidemiological characteristics and responses towards existing drugs for better patient management. Our computational analyses provided insights into infectious and pathogenic trails of the Omicron variant. In addition, while the analysis represented South Africa's Omicron variant being similar to the highly-infectious B.1.620 variant, mutations within the prominent proteins are hypothesized to alter its pathogenicity. Moreover, docking evaluations revealed significant differences in binding affinity with human receptors, ACE2 and NRP1. Owing to its characteristics of rendering existing treatments ineffective, we evaluated the drug efficacy against their target protein encoded in the Omicron through molecular docking approach. Most of the tested drugs were proven to be effective. Nirmatrelvir (Paxlovid), MPro 13b, and Lopinavir displayed increased effectiveness and efficacy, while Ivermectin showed the best result against Omicron. Comments: 30 pages, 5 figures Subjects: Other Quantitative Biology (q-bio.OT) Cite as: arXiv:2201.08176 [q-bio.OT] (or arXiv:2201.08176v1 [q-bio.OT] for this version) doi.org/10.48550/arXiv.2201.08176Focus to learn more Submission history From: Md Sorwer Alam Parvez [view email] [v1] Thu, 20 Jan 2022 13:48:12 UTC (1,310 KB) |
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Post by Walter on Mar 18, 2022 18:19:17 GMT -5
Unfortunately, there is no link to the study. Post a link to the actual study. The link was at the bottom of the page all of the resource links from the article are at the bottom of the page arxiv.org/abs/2201.08176v1Submitted on 20 Jan 2022] Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity and possible therapeutics Md Sorwer Alam Parvez, Manash Kumar Saha, Md. Ibrahim, Yusha Araf, Md. Taufiqul Islam, Gen Ohtsuki, Mohammad Jakir Hosen Prominently accountable for the upsurge of COVID-19 cases as the world attempts to recover from the previous two waves, Omicron has further threatened the conventional therapeutic approaches. Omicron is the fifth variant of concern (VOC), which comprises more than 10 mutations in the receptor-binding domain (RBD) of the spike protein. However, the lack of extensive research regarding Omicron has raised the need to establish correlations to understand this variant by structural comparisons. Here, we evaluate, correlate, and compare its genomic sequences through an immunoinformatic approach with wild and mutant RBD forms of the spike protein to understand its epidemiological characteristics and responses towards existing drugs for better patient management. Our computational analyses provided insights into infectious and pathogenic trails of the Omicron variant. In addition, while the analysis represented South Africa's Omicron variant being similar to the highly-infectious B.1.620 variant, mutations within the prominent proteins are hypothesized to alter its pathogenicity. Moreover, docking evaluations revealed significant differences in binding affinity with human receptors, ACE2 and NRP1. Owing to its characteristics of rendering existing treatments ineffective, we evaluated the drug efficacy against their target protein encoded in the Omicron through molecular docking approach. Most of the tested drugs were proven to be effective. Nirmatrelvir (Paxlovid), MPro 13b, and Lopinavir displayed increased effectiveness and efficacy, while Ivermectin showed the best result against Omicron. Comments: 30 pages, 5 figures Subjects: Other Quantitative Biology (q-bio.OT) Cite as: arXiv:2201.08176 [q-bio.OT] (or arXiv:2201.08176v1 [q-bio.OT] for this version) doi.org/10.48550/arXiv.2201.08176Focus to learn more Submission history From: Md Sorwer Alam Parvez [view email] [v1] Thu, 20 Jan 2022 13:48:12 UTC (1,310 KB) Thanks. From the study: "The binding affinity increased for Nirmatrelvir, MPro 13b, and Lopinavir (Fig 4), whereas no changes for Ivermectin, MPro N3, and GC-373. The lowest binding energy was found for Ivermectin against both wild and mutant main protease. The binding site for all drugs was similar, however, the interacted amino acids were different (Fig 5)." And then, later in the piece: "Through docking analysis, we revealed that the mutations in spike protein increased its binding affinity for its main receptor ACE2 while decreased binding affinity for its co-receptor NRP-1. All the promising drugs that target the main protease would also be effective against this variant; however, Ivermectin shows the strongest binding affinity, and Nirmatrelvir (Paxlovid), MPro 13b, and Lopinavir may be more effective against this variant. "I confess I have no idea what any of this means, but I did notice this at the top of the page: Important: e-prints posted on arXiv are not peer-reviewed by arXiv; they should not be relied upon without context to guide clinical practice or health-related behavior and should not be reported in news media as established information without consulting multiple experts in the field. As I've said, if Ivermectin can be shown to do a good job, let's sign it up and start using it. But until that occurs and some official body like the FDA signs off on it, IMO, it ain't ready for prime time. |
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Post by cbisbig on Mar 18, 2022 18:54:31 GMT -5
The link was at the bottom of the page all of the resource links from the article are at the bottom of the page arxiv.org/abs/2201.08176v1Submitted on 20 Jan 2022] Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity and possible therapeutics Md Sorwer Alam Parvez, Manash Kumar Saha, Md. Ibrahim, Yusha Araf, Md. Taufiqul Islam, Gen Ohtsuki, Mohammad Jakir Hosen Prominently accountable for the upsurge of COVID-19 cases as the world attempts to recover from the previous two waves, Omicron has further threatened the conventional therapeutic approaches. Omicron is the fifth variant of concern (VOC), which comprises more than 10 mutations in the receptor-binding domain (RBD) of the spike protein. However, the lack of extensive research regarding Omicron has raised the need to establish correlations to understand this variant by structural comparisons. Here, we evaluate, correlate, and compare its genomic sequences through an immunoinformatic approach with wild and mutant RBD forms of the spike protein to understand its epidemiological characteristics and responses towards existing drugs for better patient management. Our computational analyses provided insights into infectious and pathogenic trails of the Omicron variant. In addition, while the analysis represented South Africa's Omicron variant being similar to the highly-infectious B.1.620 variant, mutations within the prominent proteins are hypothesized to alter its pathogenicity. Moreover, docking evaluations revealed significant differences in binding affinity with human receptors, ACE2 and NRP1. Owing to its characteristics of rendering existing treatments ineffective, we evaluated the drug efficacy against their target protein encoded in the Omicron through molecular docking approach. Most of the tested drugs were proven to be effective. Nirmatrelvir (Paxlovid), MPro 13b, and Lopinavir displayed increased effectiveness and efficacy, while Ivermectin showed the best result against Omicron. Comments: 30 pages, 5 figures Subjects: Other Quantitative Biology (q-bio.OT) Cite as: arXiv:2201.08176 [q-bio.OT] (or arXiv:2201.08176v1 [q-bio.OT] for this version) doi.org/10.48550/arXiv.2201.08176Focus to learn more Submission history From: Md Sorwer Alam Parvez [view email] [v1] Thu, 20 Jan 2022 13:48:12 UTC (1,310 KB) Thanks. From the study: "The binding affinity increased for Nirmatrelvir, MPro 13b, and Lopinavir (Fig 4), whereas no changes for Ivermectin, MPro N3, and GC-373. The lowest binding energy was found for Ivermectin against both wild and mutant main protease. The binding site for all drugs was similar, however, the interacted amino acids were different (Fig 5)." And then, later in the piece: "Through docking analysis, we revealed that the mutations in spike protein increased its binding affinity for its main receptor ACE2 while decreased binding affinity for its co-receptor NRP-1. All the promising drugs that target the main protease would also be effective against this variant; however, Ivermectin shows the strongest binding affinity, and Nirmatrelvir (Paxlovid), MPro 13b, and Lopinavir may be more effective against this variant. "I confess I have no idea what any of this means, but I did notice this at the top of the page: Important: e-prints posted on arXiv are not peer-reviewed by arXiv; they should not be relied upon without context to guide clinical practice or health-related behavior and should not be reported in news media as established information without consulting multiple experts in the field. As I've said, if Ivermectin can be shown to do a good job, let's sign it up and start using it. But until that occurs and some official body like the FDA signs off on it, IMO, it ain't ready for prime time. Dig deeper 151 ivermectin COVID-19 studies, 102 peer reviewed, 81 comparing treatment and control groups. Recently added:Lawrie Soto Efimenko Thairu Lim. Ivermectin has been officially adopted for early treatment in all or part of 22 countries (39 including non-government medical organizations). Submit updates/corrections . c19ivermectin.com/ |
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Post by Panama pfRedd on Mar 18, 2022 19:05:42 GMT -5
Thanks. From the study: "The binding affinity increased for Nirmatrelvir, MPro 13b, and Lopinavir (Fig 4), whereas no changes for Ivermectin, MPro N3, and GC-373. The lowest binding energy was found for Ivermectin against both wild and mutant main protease. The binding site for all drugs was similar, however, the interacted amino acids were different (Fig 5)." And then, later in the piece: "Through docking analysis, we revealed that the mutations in spike protein increased its binding affinity for its main receptor ACE2 while decreased binding affinity for its co-receptor NRP-1. All the promising drugs that target the main protease would also be effective against this variant; however, Ivermectin shows the strongest binding affinity, and Nirmatrelvir (Paxlovid), MPro 13b, and Lopinavir may be more effective against this variant. "I confess I have no idea what any of this means, but I did notice this at the top of the page: Important: e-prints posted on arXiv are not peer-reviewed by arXiv; they should not be relied upon without context to guide clinical practice or health-related behavior and should not be reported in news media as established information without consulting multiple experts in the field. As I've said, if Ivermectin can be shown to do a good job, let's sign it up and start using it. But until that occurs and some official body like the FDA signs off on it, IMO, it ain't ready for prime time. Dig deeper 151 ivermectin COVID-19 studies, 102 peer reviewed, 81 comparing treatment and control groups. Recently added:Lawrie Soto Efimenko Thairu Lim. Ivermectin has been officially adopted for early treatment in all or part of 22 countries (39 including non-government medical organizations). Submit updates/corrections . c19ivermectin.com/Deaf ears. Doesn't fit the desired narrative. |
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................................  ................................ = Panama pfRedd - 2021 Regular Season Champion = ...............................  ................................
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